This issue is usually caused by a mismatched setting. Verify that you have properly configured all of the settings below (pay careful attention to "Margins" and "Headers and Footers" for this issue).
Select ‘More Settings’
Set Layout to ‘Landscape’
Select ‘30258 Diskette’ as the paper size
Note: Due to a recent update of Chrome, some users may not see the expected paper sizes. If you do not see '30258 Diskette', look for "custom 54.02x69.85mm" until this issue between Dymo and Chrome is resolved.
Set Margins to 'Minimum'
Set Scale to 'Default'
Ensure that the check boxes for 'Headers and footers' and 'Background graphics' are NOT checked